One day the Four Horsemen of the Apocalypse - Pestilence, Famine, War and Death, bored with waiting for the end of the world descend to Earth from the Fourth Dimension, a supernatural place that intertwines with the world of mortals. They are on the run from God, who has issued a letter of introduction after them for unknown reasons. It turns out that War has fallen in love with a mortal girl, a student at the high school he and his brothers immediately enroll in. All four have trouble adjusting to earthly life, especially Pestilence, who regularly makes use of his powers to infect people with all sorts of diseases.
