Ayesha was the Golden High Priestess of the Sovereign, a race created by the High Evolutionary. She hired the Guardians of the Galaxy to protect Anulax Batteries from an Abilisk, but after Rocket Raccoon stole several of the batteries with the intention to later sell them, she became enraged and sent her fleet of Omnicrafts to kill them. The Guardians managed to escape through a Quantum Asteroid Field, and Ayesha later hired Yondu Udonta and his Ravagers to complete the task, only to later be betrayed by him. After gaining information from Taserface, Ayesha's army was unsuccessful in another attempt to destroy the Guardians. Ayesha then created the Sovereign's greatest weapon, Adam Warlock, to finally get revenge on the Guardians. She and Warlock worked with the High Evolutionary to capture Rocket Raccoon, before Ayesha was caught in an explosion on Counter-Earth and killed by her creator.