The Brain the main antagonist of Animaniacs, the overall titular deuteragonist of its spinoff Pinky and the Brain and Pinky, Elmyra and the Brain, and the main antagonist of the crossover series, The Plucky Duck Italian Adventures.
Obviously, don't nominate any human characters. Hybrids like Cheetah or The Lizard are okay, as are shapeshifters with one set animal form (eg Professor McGonagall.)
