Perdita is the female protagonist of the 1961 Disney animated feature film One Hundred and One Dalmatians. She is the pet of Anita, mate of Pongo, the biological mother of 15 Dalmatian puppies and the adoptive mother of 84 more Dalmatian puppies.
Obviously, don't nominate any human characters. Hybrids like Cheetah or The Lizard are okay, as are shapeshifters with one set animal form (eg Professor McGonagall.)