The main antagonist of Kirby: Triple Deluxe. Sectonia was once a fair ruler before she was corrupted by a cursed mirror, becoming a vain, socipathic tyrant. But worst of all, she's a wasp. (Not a WASP, though)
Obviously, don't nominate any human characters. Hybrids like Cheetah or The Lizard are okay, as are shapeshifters with one set animal form (eg Professor McGonagall.)