The show follows three stories. First a dysfunctional, blended family composed of Madison Clark (Kim Dickens), her fiancé Travis Manawa (Cliff Curtis), her daughter Alicia (Alycia Debnam-Carey), her drug-addicted son Nick (Frank Dillane) and Travis' son Chris (Lorenzo James Henrie). The second a Lieutenant who encounters the effects of a virus. Last a scientist who discovers the spread of a new virus. At the onset of the zombie apocalypse, their group includes Victor Strand (Colman Domingo), a smart and sophisticated conman-turned-businessman, Daniel Salazar (Rubén Blades) and his daughter Ofelia (Mercedes Mason). Meanwhile the two individuals cross paths and try to survive. While the other individuals cross paths and group together. Each group navigates through Los Angeles in search of a safe haven.
