Scientist Reed Richards (John Krasinski) persuades his arrogant former classmate, Victor von Doom (Cillian Murphy), to fund his experiments with cosmic energy. On von Doom's space station, the crew -- including astronaut Ben Grimm (Jason Segel), researcher Sue Storm (Emily Blunt) and pilot Johnny Storm (Zac Efron) -- are exposed to a mysterious cosmic storm that bestows super powers upon them. As they cope with their transformations, von Doom vows his revenge.