Emmet Reese wants to become a wolf now after married to Lucy Talbot. So Randy Kleinbach returns who presents his latest ray, The Animalfication Ray. A ray that turns animals into humans and humans into animals. However, his ray shoots and results into Emmet transforming into a Great Plains wolf, Roger into a human, Lisa Hughes, Lucy Talbot and Colin Stark transforming into animals, and Gwen, Maria and Lawrence turns into humans. Roger steals the ray and escapes with Emmet Reese, handing it to Emilithara Thornshade, for safekeeping. They're the W.O.L.F. gang have plan to stop the Vees. However, Randy laments the Vees' betrayal and decides to give up villainy, sending Roger away. During a London, Emmet, Roger and Emilithara find each other with the ray but are cornered by the Vees, who in turn are confronted by Heroic Wolf League agents. The Vees then use the ray transforming themselves into animals and prepare to kill Roger by tying him to the hands of a clock tower to rip him apart. However, Randy returns and fight the Vees with Lucy and Lisa, the girls battles the Vees while Emmet saves Roger, but Randy has defeated by the Vees when trying the ray back. After Emmet and Lucy knock the Vees out, Roger uses the ray to turn them into rats. Congratulating Emmet, Lucy, and Lisa saving Roger's life, the Vees are arrested and Randy Kleinbach was taken to Mental Asylum, Lisa turns Emmet, Roger and Lucy back to normal.
