A mysterious deadly illness is unleashed among the children in the town of Edo. This strange phenomenon has reached the ears of both Gintoki and Josuke, as they try to investigate what's behind the mysterious plague. At the same time, a number of bizarre deaths occurred, as Josuke soon discovers that the murderer isn't human! Eventually, he crosses paths with Mukuro and Okiku again after the events of season 1. Suspecting them to be the ones responsible for all the trouble that's been happening, Josuke continues to look for the answers. During the night of the crescent moon, all have descended into chaos as mysterious monsters known as Ashura/Shura suddenly appears. These monsters were revealed to have been controlled by a mysterious man in black who has some kind of connections to Gintoki, doubled with the sudden appearance of Sakamoto Ryoma, an old friend of Gintoki from Tosa domain, who seems to be secretly allying himself with Gintoki and the gang, as he claims that somebody is going after him. Meanwhile, on his quest to solve all these mysteries, Josuke reunites with his older brother, who was revealed to be alive, but he's not the same as he used to be. What is the meaning behind all of this ? This story will focus on Josuke's adventures and will have a combination of samurai action and supernatural horror elements as well as violence and psychological thriller.
