The series revolves around two stepbrothers, Drake Parker and Josh Nichols, who live in San Diego, California with their biological parents and their younger sister Megan. Drake is a popular musician idolized by his schoolmates. Josh Nichols is a well-read student, but is clumsy and has trouble with his social life and dating. The two boys are often involved in comedic escapades and challenges while also handling an array of teenage problems.