Continuing the adventures of our resident devil hunter. Dante is visited by a strange man named Arkham, who notifies him that Dante's brother is looking for him. A great tower named Temen-ni-gru suddenly erupts out of the ground soon after, unleashing hordes of demons upon the city.
Dante, always ready for a fight, sets off to conquer the tower, encountering swarms of demons and the like. Dante's twin brother, Vergil, works with Arkham to release the ancient tower of Temen-ni-gru and conspire to use Dante to unlock the gate to the demonic realm.
While working toward confronting his brother, Dante encounters a gun-toting lady who still refuses to give him her name, and the mysterious Jester, an enigmatic clown that aids Dante throughout his journey.
