In February 2079, a genetically enhanced nine-year-old female supersoldier designated as X5-452 (Geneva Locke) escapes along with eleven others from a secret U.S. government institution code-named Manticore, where they were born, raised, and trained to be soldiers and assassins. On June 1, 2009, months after X5-452's escape, terrorists detonate an electromagnetic pulse weapon in the atmosphere over the U.S., which destroys the vast majority of computer and communication systems, throwing the country into chaos.
