Ten years after a devastating error, devoted family man Chas encounters the enigmatic occult investigator John Constantine. Chas pleads with John to assist his daughter Trish, who has mysteriously slipped into a coma, a condition Chas fears may be linked to dark sorcery. John employs his magical abilities on Trish and uncovers that her aura is corrupted. Renne, Chas' estranged wife, adds to the complexity of the situation. With the aid of the elusive Nightmare Nurse, the powerful Queen of Angels, and the fierce Aztec deity Mictlantecuhtli, the duo may just have a fighting chance to outwit the demon Beroul and rescue Trish's soul.