Recently released army ranger Cameron Poe is on his way to reunite with his wife, but he is forced to travel on a prison transport flight known as "Jailbird" alongside some of the most dangerous criminals. In the company of Diamond Dog and Baby-O, the notorious serial killer Cyrus "The Virus" Grissom orchestrates a violent escape plan while in mid-flight. Poe, secretly collaborating with U.S. Marshall Vince Larkin, endeavors to thwart Grissom's scheme.
