After the events of the first film, Chip and Dale are back and on the top of the world, however not all is well as several prominent cgi toons from characters like Woody and Buzz from Toy Story and Carl and Dug from Up alongside many others as it seems the residents of the uncanny valley want revenge on the people who made them by destroying these beloved icons with a new invention called the Depixelzer that is capable of what dip can do to traditional toons and permanently kill off these toons for good.
