Makkari is a member of a community of the genetically-engineered Eternals, created at the World Forge by the Celestials, who came to Earth in 5,000 B.C. to help progress Earth's societal development and protect it from the Deviants. In Ancient Mesopotamia, she developed an affinity towards Druig and the Humans alike. In 1521 A.D., after completing her prime goal of defeating the Deviants, she and the other Eternals decided to disband and separate. Makkari decided to relocate to the Domo, buried under Iraq, where she started her goal to explore the Earth and collect various objects and artifacts. In the wake of the Blip, Makkari was summoned by Sersi to rejoin the Eternals to stop the Emergence. After stopping Tiamut the Communicator from emerging and destroying Earth, and the sudden disappearance of Sersi, Phastos and Kingo, Makkari and the remaining Eternals were greeted by Starfox and Pip the Troll as a glimmer of hope.