In the 1930s, the Warner siblings, Yakko, Wakko, and Dot, were three cartoon stars who were locked away in the real-life Warner Bros. Water Tower because they were seen as too zany.[1] Several decades later, the trio escapes from the tower,[1] interacting with Warner Bros. studio workers, including Ralph the Security Guard, archrival Dr. Otto Scratchansniff, and Hello Nurse.[2] Pinky and the Brain are two genetically altered anthropomorphic laboratory mice who continuously plot and attempt to take over the world.[3][4] The segments would begin with Brain asking, "Are you pondering what I'm pondering?" before Pinky would respond with a non sequitur.[2] Slappy Squirrel is an octogenarian squirrel cartoon star paired with her nephew, Skippy.[2] The Goodfeathers trio, Bobby, Pesto, and Squit, are pigeons from New York based on the characters Henry Hill, Jimmy Conway, and Tommy DeVito from Goodfellas (1990).[5] Buttons is a pooch who risks his life to protect his four-year-old owner, Mindy.[4] Rita and Runt are a homeless cat-and-dog duo,[4] being dropped after the first season.[6] Katie Ka-Boom is a teenager with a temper.[4] Chicken Boo is a giant chicken who wishes to live among humans.[4][7] Additional side characters include the Hip Hippos.[1]