Mama Mousekewitz is the matriarch of the Mousekewitz family. She appears in all four movies and in Fievel's American Tails. She was voiced by the late Erica Yohn in every film save for An American Tail: The Mystery of the Night Monster, where she was voiced by Jane Singer. In Fievel's American Tails, she was voiced by Susan Silo. In Fievel's New York Tails, She is voiced by Tress MacNeille.