Casino follows Sam "Ace" Rothstein (De Niro), a Jewish American gambling expert handicapper who is asked by the Chicago Outfit to oversee the day-to-day casino and hotel operations at the Tangiers Casino in Las Vegas. Supporting characters include Nicholas "Nicky" Santoro (Pesci), a "made man" and friend of Ace, and Ginger McKenna (Stone), a streetwise chip hustler whom Ace marries and has a daughter with. The film details Ace's operation of the casino, the difficulties he confronts in his job, the Mafia's involvement with the casino, and the gradual breakdown of his relationships and standing, as Las Vegas changes over the years.
The primary characters are based on real people: Ace is inspired by the life of Frank Rosenthal, also known as "Lefty," who ran the Stardust, Fremont, Marina, and Hacienda casinos in Las Vegas for the Chicago Outfit from the early 1970s until 1981. Nicky and Ginger are based on mob enforcer Anthony Spilotro and former dancer and socialite Geri McGee, respectively.
