When a man simply known as Edward (Richard Arlen) is shipwrecked on an island, he notices strange things happening. It starts to become normal when his fiance (Leila Hyams) arrives, and a beautiful young native (Kathleen Burke) starts to fall in love with him. But the native has secrets, secrets that truly no ordinary human would believe, and it all traces back to her 'father' (Charles Laughton) and his scientific research. What is the secret behind the mysterious yet exotic native known only as Lota? What unearthly experiment is her 'father' trying to prove? What is there inside Moreau's House of Pain? Will Edward escape in one piece? And what is the truth behind the natives on Doctor Moreau's "Island of Lost Souls"?