Once again, Bruce Wayne has been kidnapped, but unlike the previous two times, he was only preparing to confront one of his rogues that broke out of Arkham Asylum. Now, Batman is trapped inside the facility and must fight his way through different opponents of his that he locked up, before eventually confronting Hugo Strange, who Bruce learns was never a therapist for the villains that found themselves in the prison, but instead, a madman in his own right.