Four years have passed ever since Harley Quinn and The Ventriloquist were locked up in Arkham Asylum as Bruce Wayne (Mel Gibson) is setting up to retire the role of Batman after the painful attacks from the two individual lunatics, however in the newest nightclub in Gotham known as the Iceberg Lounge that is owned by well known crime kingpin, Oswald Cobblepot (Joe Pesci) has been slowly taking over Gotham's crime ridden underbelly, having half of the inhabitants in his pocket. Starting from corrupt officials in the Gotham City Police Department, to some of even the high-living officials in the city, but things get even worse as there was an escaped inmate of an island prison in South America finds his way to Gotham, Eduardo Dorrance. A dangerous criminal that just escaped from an experiment gone wrong involving a unknown drug known as Venom.
Meanwhile, the famous Gordon family including Barbara Gordon (Molly Ringwald) are planning to move away from Gotham City after Barbara was nearly killed at the hands of Harley Quinn but heard about the newest criminal. However, what Gotham didn't know was that they will experience the bane to Gotham's existence once a large breakout of Arkham starts after Dorrance made a deal with Cobblepot, now for the first time. Gotham's residents, including Batman weren't prepared for what's to come..
