Dr. Doom has obtained the Soul Stone from Wakanda and with the Dimensional Transportation machine, Doom transports various Heroes to the Negative Zone so she can continue with her plans unhindered. The heroes are overwhelmed by the Negative Zone's native creatures Insectoids, but are rescued by the Fantastic Four. Together with the Fantastic Four, the heroes find Annihilus, the ruler of the Negative Zone, and defeat her, obtaining her Cosmic Control Rod and using it to open an inter-dimensional bridge gate to escape. The heroes emerge from the gate in Latveria, discovering that many of its people have been absorbed into the Soul Stone. They make their way to Castle Doom, where Doom reveals that she is using her people's souls to resurrect a Celestial. The heroes defeat the Celestial, but Doom uses the cosmic power from the Soul Stone to transform herself into Goddess Emperor Doom. The heroes ultimately triumph over Doom, freeing the souls of the Latverian citizens and reviving them. Afterwards, Mrs. Fantastic reveals that Doom's plans were meant to protect the universe from unknown entities awakened by Thanas, and the heroes agree to prepare for future Invasions and plan to join forces yet again against this new threats.
