The universe based on the main MCU, but Cold War still existed, North Japan, India, and Latin America turned 'Red'. The main plot started since 2018, after two global terrorist attacks in 2015 and 2017. Also, Thanos gets defeated earlier to make way for the civil war between capitalist and socialist heroes. The MCU styled animated series would be an ironic thing after DC Comics released its animated movies 'Red Son' and 'Injustice'.
