"Spider-Man" centers on student Peter Parker (Tobey Maguire) who, after being bitten by a genetically-altered spider, gains superhuman strength and the spider-like ability to cling to any surface. He vows to use his abilities to fight crime, coming to understand the words of his beloved Uncle Ben: "With great power comes great responsibility."
This is all the movies, and their casts, in my timeline of the 2000s Marvel movies. If I took out some, added more, and rewrote a lot more, that's what this would be. There will be more movies to come in this timeline. BTW, Days of Future Past is what originally changes the timeline.