The plot is set in a fictional history of real-world events and follows the centuries-old struggle between the Assassins, who fight for peace with free will, and the Knights Templar, who desire peace through control. The framing story is set in the 21st century and follows Desmond Miles as he relives the genetic memories of his ancestor Ezio Auditore da Firenze to uncover the mysteries left behind by an ancient race known as the First Civilization in the hope of ending the Assassin-Templar conflict. The main narrative takes place at the height of the Renaissance in Italy during the late 15th century, and follows Ezio's journey as an Assassin while seeking revenge against those responsible for the death of his father and brothers.
