The framing story is set in the 21st century and follows Desmond Miles as he relives the genetic memories of his ancestor, Ezio Auditore da Firenze, to uncover the mysteries left behind by an ancient race known as the First Civilization in the hope of ending the Assassin-Templar conflict. The main narrative takes place at the height of the Renaissance in Italy from 1476 to 1499, and follows Ezio's journey as an Assassin while seeking revenge against those responsible for the death of his father and brothers.
