The universe stands on the brink of annihilation as Annihilus and his relentless Annihilation Wave sweep across the stars, leaving destruction in their path. With the Harvester of Sorrows a massive organic weapon capable of amplifying the Wave’s devastation—threatening to extend the carnage beyond known worlds, the Fantastic Four ally with Super Skrull to infiltrate the Negative Zone. Their mission: uncover the Harvester’s secrets and stop Annihilus from turning Galactus into his ultimate weapon of conquest. Across the galaxy, the Guardians of the Galaxy split their forces, with Star-Lord’s team sabotaging the Harvester from within while Rocket, Groot, Nova, Adam Warlock, and others defend vulnerable systems. Captain Marvel and Monica Rambeau rally S.A.B.E.R. to lead counterattacks and protect what remains of civilization, while the Annihilators race to free Silver Surfer and reach Galactus before Annihilus can exploit his power. As all fronts converge in a final, desperate stand, every alliance and sacrifice will determine whether the universe survives—or falls into total devastation.
