The Warner Brothers and the Warner Sister, Yakko (Rob Paulsen), Wakko (Jess Harnell), and Dot (Tress MacNeille), along with their new friends Trixie (Kath Soucie), Moxy (E.G. Daily), and Nat Magee (Tara Strong), have to save the future of the cartoon industry from the Chairman of Warner Bros., Silas Plotz, (the son of Thaddeus Plotz), who wants all the toons of Warner Bros. to be erased.