The series chronicles the adventures of an independent, fearless and brave Thai-American girl named Anne Boonchuy. On her 13th birthday, Anne is peer-pressured into stealing a mysterious music box (known as the Calamity Box) that magically transports her and her two best friends Sasha Waybright and Marcy Wu to the world of Amphibia, a wild marshland tropical island full of anthropomorphic amphibians and threatening creatures, where they are separated from each other. Anne is taken in by the Plantars, a family of frogs that consists of excitable young Sprig; unpredictable and adventurous baby pollywog Polly; and overprotective and traditional grandfather Hop Pop who live on a farm in the town of Wartwood. As she bonds with her newfound family, Anne gradually learns what it means to be a hero and develop a true friendship, all the while trying to find her friends and return home. Sasha allies with Captain Grime, leader of the warfaring toads of Toad Tower, who seek to control their home of Frog Valley. Marcy ends up in Newtopia, the capital of Amphibia and the seat of the government and home to the king of Amphibia.
