Set in New Orleans in 1939, it tells the story of Charlie B. Barkin (voiced by Burt Reynolds), a German Shepherd that is murdered by his former friend, Carface Carruthers (voiced by Vic Tayback). Charlie escapes from Heaven to return to Earth where his best friend, Itchy Itchiford (voiced by Dom DeLuise), still lives, in order to take revenge on Carface. Instead, he ends up befriending a young orphan girl named Anne-Marie (voiced by Judith Barsi in her final film role). In the process, Charlie learns an important lesson about kindness, friendship and love.
